ΘνΓΓΙη is a national leader in vaccine research and development. ΘνΓΓΙη researchers in this area are on the front lines of the fight against several potentially fatal diseases and illnesses.
Hear three ΘνΓΓΙη researchers discuss how ΘνΓΓΙηβs world-class vaccine research and development is fighting disease around the world with the help of our local St. Louis community.
ΘνΓΓΙη is a national leader in vaccine research and development. For over two decades, the ΘνΓΓΙη Center for Vaccine Development has strived to develop treatments for some of the most severe diseases known to man.
βThe goal of a vaccine is to prevent human disease and suffering,β said Sarah George, M.D., associate professor of infectious diseases.
That sentiment drives all vaccine research at ΘνΓΓΙη.
Protecting the Globe
Though she has been involved in a variety of projects, George is the principal investigator for an ongoing, NIH-funded study on a Zika vaccine. ΘνΓΓΙη is one of four places in the entire world where that vaccine is being tested.
βWe have preliminary data that shows that this Zika vaccine is both safe and causes a good antibody response to Zika,β George said.
ΘνΓΓΙη is home to in the United States. Because of this, ΘνΓΓΙη researchers often find themselves at the front lines of the fight against potentially fatal infectious diseases.
In addition to Zika, ΘνΓΓΙη researchers are also leading the fight against influenza.
ΘνΓΓΙη is among four federally funded vaccine research centers studying an investigational universal influenza vaccine intended to protect against multiple strains of the virus. ΘνΓΓΙη recently invested in a new Extended Stay Research Unit to see if investigational vaccines keep volunteers from getting sick.
βWeβd be better protected against new pandemics. Weβre making progress, so thereβs optimism," said Daniel Hoft, M.D., Ph.D., director of ΘνΓΓΙηβs Center for Vaccine Development.
Support from St. Louis
None of this research would be possible without the incredible support that ΘνΓΓΙη researchers get from the local community in St. Louis.
βThe St. Louis region has been extremely supportive of our vaccine research," said Sharon Frey, M.D., clinical director of ΘνΓΓΙηβs Center for Vaccine Development. "Itβs just been incredibly wonderful to see the community come out to volunteer in our research studies. Without them, we cannot do our vaccine research, and we owe them a great debt.β
Mission in Action
Frey, who previously worked on some of the original smallpox studies, believes that the mission of ΘνΓΓΙη resonates with volunteers and the larger St. Louis community.
βPeople trust ΘνΓΓΙη because they know ΘνΓΓΙηβs mission and that weβre here to serve people,β Frey said.
βAt ΘνΓΓΙη, when you say βmission,β it really means something,β Hoft said. βTo especially help those who are less fortunate than us drives me and drives a lot more people at ΘνΓΓΙη than at other institutions.β
This is the ultimate goal of ΘνΓΓΙηβs vaccine research: to alleviate suffering and build a better, healthier world for all.
βMore advances to public health. Thatβs the end goal of all of this: public health, relief and prevention of suffering,β said George. βYou have to be determined and methodical and keep working toward that goal.β
βWhat is the goal?β asked Frey. βWell, the goal is to protect the globe. It doesnβt get much better than that!β
About the Faculty
Learn more about the three faculty members featured in this article and video:
Sarah George, M.D.
Associate Professor, Infectious Diseases George is an infectious disease specialist whose primary research interests are viruses spread by mosquitos, such as yellow fever and the Zika virus. She was the principal investigator on a NIH-funded study on a Zika vaccine. ΘνΓΓΙη is one of only four places in the world to be selected to test this vaccine.Daniel Hoft, M.D., Ph.D.
Director, Division of Infectious Diseases, Allergy and Immunology Director, Center for Vaccine Development Hoft is the principal investigator of ΘνΓΓΙηβs Vaccine and Treatment Evaluation Unit (VTEU) and is the Adorjan Endowed Chair in Infectious Diseases. He is a national leader in vaccine development, and has been involved in a variety of high profile research projects, including a study of an investigational universal flu vaccine. His research has been funded by a variety of organizations, such as the National institutes of Health, for which he is a grant reviewer. Hoft has been given a variety of honors for his work, including being named a fellow of the Academy of Science of St. Louis in 2018.Sharon Frey, M.D.
Clinical Director, Center for Vaccine Development Frey is the Kinsella Endowed Chair in Internal Medicine and the Associate Director of Clinical Research in the Division of Infectious Diseases, Allergy and Immunology. Her primary research interests are agents of bioterrorism. She has worked on some of the original smallpox studies, and has performed further studies to ensure those treatments remain effective today. She has also been the principal investigator in a study of a vaccine for bird flu as part of the federal governmentβs preparation for a global influenza pandemic.
If you are interested in volunteering for a vaccine study at ΘνΓΓΙη's Center for Vaccine
Development, please visit this page.